Further, it is common to have effects ranging from beneficial to adverse for one substance when going from low to high doses.
[3] Because of the costs of the measurement, biological activities are often predicted with computational methods, so-called QSAR models.
In the biological environment, the formation of a layer of carbonated hydroxyapatite (CHA) initiates bonding to the bone tissues.
The bioglass surface coating undergoes leaching/exchange of ions, dissolution of glass, and formation of the HA layer that promotes cellular response of tissues.
In the study of biomineralisation, bioactivity is often meant to mean the formation of calcium phosphate deposits on the surface of objects placed in simulated body fluid, a buffer solution with ion content similar to blood.