Biotin deficiency is a nutritional disorder which can become serious, even fatal, if allowed to progress untreated.

Biotin deficiency rarely occurs among healthy people because the daily requirement of biotin is low, many foods provide adequate amounts of it, intestinal bacteria synthesize small amounts of it, and the body effectively scavenges and recycles it in the kidneys during production of urine.

[1][4] The prognosis for congenital MCD is good if biotin supplementation is begun quickly after birth and carried on throughout the patients life.

[24] In the United States, biotin supplements are readily available without a prescription[25] in amounts ranging from 300 to 10,000 micrograms.

[26] 30 micrograms daily is identified as Adequate Intake for men and women 19 years and older.