It was depopulated during the 1948 Arab-Israeli War on July 15, 1948 during the second phase of Operation Danny by the First and Second Battalions of the Yiftach Brigade.

He was told that the village mosque was consecrated to its founder, Neby Ma'in, son of Jacob (which may be identical to Benjamin).

When he died, his five sisters hurried to Bir Ma'in from Jiser Benat Ya'kub ('Jacob Daughters' Bridge').

[11] In 1596 Bir Ma'in appeared in the tax registers being in the nahiya ("subdistrict") of Ramla, which was under the administration of the Gaza Sanjak.

[13] They paid a fixed tax-rate of 25 % on agricultural products, including wheat, barley, summer crops, olive trees, sesame, goats and beehives, in addition to occasional revenues and a press for olive oil or grape syrup; a total of 3,500 akçe.

In 1883, the PEF's Survey of Western Palestine described Bir Main as "A small hamlet on high ground, with a well about half a mile south-east.

[17] In the 1922 census of Palestine conducted by the British Mandate authorities, Bir Ma'in had a population of 289 inhabitants; all Muslims,[18] increasing in the 1931 census when Bir Imma'in had 355 Muslim inhabitants, in a total of 85 houses.

[5] Bir Ma'in became depopulated during the 1948 Arab-Israeli War on July 15, 1948 during the second phase of Operation Danny by the First and Second Battalions of the Yiftach Brigade.