The town was founded on December 7, 1911 by Mr. Nicolau da Silva Nunes, an entrepreneurial Portuguese native of the Parish of Moutamorta, Trás-os-Montes.

The name Birigui originated in the Tupi-Guarani language, the Indians used this word as the meaning of "fly that always comes" to a tiny hematophagous mosquito that bothered everyone and was quite frequent in the region.

To avoid frightening his customers, he used trickery, he asked, until they had erased the Indians' trail and moved in two wagons to demonstrate security.

Lucas Scarpin, Antonio Simões, Faustino Segura, Ricardo Del Nery, João Galo, France Contel and Giuzeppe Fonzar were some of the pioneers.

In 1912, Birigui gains another inhabitant, José Cordeiro, a typical bandeirante captain who leaves Lençóis Paulista with his expedition and joins the town.

Manuel Bento da Cruz founded the company of Lands, Timber and Colonization São Paulo, with as pioneers Roberto Clark and James Mellor.

The soccer team, Bandeirante Esporte Clube, was founded on March 11, 1923 and its first president was José Troncoso, who currently names a street in the city.

In 1987 the team played professionally in the Premier League of Campeonato Paulista (a championship in the state of São Paulo) Biribol was invented in the city by the Teacher Dario Miguel Pedro.