The building and the adjacent cemetery were near the center of fighting on the afternoon of September 11, 1777 at the Battle of Brandywine.

The Continental forces rushed north to meet the British in the area of the meetinghouse.

After the battle, dead British and American soldiers shared a common grave in the cemetery.

In 1968 Quaker architect Mather Lippincott designed a new education building to the north of the meeting house.

[7] From 1845 to 1923 a group of Quakers worshipped a few hundred yards south at the Orthodox Meetinghouse as a result of the Hicksite-Orthodox split.