The exterior of the theatre was substantially rebuilt by Associated Architects and Law and Dunbar-Nasmith in 2001, with a new glass facade and accommodation for the Birmingham Royal Ballet and additional performance space.

[citation needed] The Hippodrome has since presented large scale West End touring musicals and plays, such as Blood Brothers, Wicked, The Lion King, Matilda, Mary Poppins, Annie, Grease, Les Misérables, The Phantom of the Opera, War Horse, Billy Elliot, Mamma Mia!, We Will Rock You, The Curious Incident of the Dog in the Night-Time and Hamilton.

The theatre has also hosted numerous dance productions from Matthew Bourne's company New Adventures such as Swan Lake, Nutcracker!, Edward Scissorhands and The Red Shoes.

[8] In September 2022, the theatre presented the world premiere of Peaky Blinders: The Redemption of Thomas Shelby by Rambert Dance, based on the TV series of the same name, prior to touring the country and returning to the Hippodrome, before being filmed for the BBC.

[9] The theatre's Christmas pantomimes are produced by Crossroads Pantomimes (previously Qdos Entertainment) over recent years attracting stars such as Brian Conley, Don Maclean, Julian Clary, Joe Pasquale, John Barrowman, The Grumbleweeds, Paul Zerdin, Ray Quinn, Joan Collins, Nigel Havers, Keith Harris, Lynda Bellingham, Basil Brush, Lesley Joseph, Gok Wan, John Partridge, Stephanie Beacham, Gary Wilmot, Jane McDonald, Duncan James, Chris Gascoyne, Marti Pellow, Lee Mead, The Krankies, Steve McFadden, Jodie Prenger, Beverley Knight, Danny Mac, Suzanne Shaw, Jimmy Osmond, Darren Day, Meera Syal, Jaymi Hensley, Joe McElderry, Faye Brookes, Jason Donovan, Alexia McIntosh, Ranj Singh, Alison Hammond and Samantha Womack.