After that day, the News and its two sister Alabama newspapers, the Press-Register in Mobile and The Huntsville Times, moved to a thrice-weekly print-edition publication schedule (Sundays, Wednesdays and Fridays).

Rhodes supported construction of a viaduct across "Railroad Reservation" dividing north and south Birmingham.

The "News Bridge" (21st Street Viaduct) was dedicated on July 4, 1891, which Rhodes' paper hailed as the "grandest of all municipal achievements of great and glorious Birmingham."

A year later the paper made good use of its new space by purchasing the rival Birmingham Ledger, increasing the size of its staff to 748 and its circulation to 60,000.

The News press printed both papers and handled advertising and subscriptions sales while the editorial and reporting staffs remained independent.

The agreement lasted until the Post-Herald ceased publication in September 2005, leaving the News as Birmingham's only daily newspaper.

In 1956, the Hanson family sold the News to S. I. Newhouse Sr.'s Advance Publications in New York for $18 million, the largest sum that had been paid at the time for a daily newspaper.

The privately held Advance continues to own the News as well as The Huntsville Times and Mobile's Press-Register, the three largest newspapers in Alabama, as well as their shared website, al.com.

The 1917 building was demolished in 2008 in order to make room for a surface parking lot serving employees of the paper.

On January 22, 2013, Alabama Media Group announced it was selling the building, saying the high-tech, modern and open facility was not conducive to its digital-first, print-last operations.

[7] On May 24, 2012, Advance Publications announced that its three Alabama newspapers would do away with print editions on Mondays, Tuesdays, Thursdays and Saturdays.

[8] The changes took effect on October 1, 2012, making Birmingham the second-largest city in the United States to not be served by a daily newspaper; New Orleans became the largest that same day.

On November 3, 2022, Advance management announced that the News, as well as its sister newspapers in Huntsville and Mobile, would discontinue its print edition on February 26, 2023, and convert to an all-digital operation.

In 2006, staff photographer Bernard Troncale took top honors at the Society of Professional Journalists' Green Eyeshade Awards for his work on a series about AIDS in Africa.

In 2018, columnist John Archibald won the Pulitzer Prize for Commentary for his columns about former governor Robert J. Bentley, former Alabama Chief Justice Roy Moore and corruption in state politics.

John Archibald, Ashley Remkus, Ramsey Archibald, and Challen Stephens won the 2023 Pulitzer Prize for Local Reporting for a series on a scandal in Brookside, Alabama where police officers had engaged on a rampant campaign of fining and towing motorists to corruptly keep the proceeds on fabricated charges.