When Wilke was in her teens, she won a talent competition at the National Scala Theatre in Copenhagen, sang as soloist with Bruno Henriksen's Orchestra at Tivoli Gardens in Copenhagen, made her first recording, and was named "Denmark's Doris Day" and recorded "Que sera sera" in 1956.

After qualifying in the Dansk Melodi Grand Prix to represent Denmark at the Eurovision Song Contest, she participated in the Eurovision Song Contest 1957, where she sang "Skibet Skal Sejle I Nat" ("The Ship Is Leaving Tonight") with Gustav Winckler.

She also participated in the Eurovision Song Contest 1959 where she sang solo "Uh-Jeg Ville Ønske Jeg Var Dig" ("Oh – I wish I were you").

In the late 1950s she toured Poland, West Germany and United States.

In addition to her recording successes, she participated in radio, television, advertising and commercial film.