Bishop Byrne was established in 1965 to serve students in the South Memphis area.

[2] Bishop Byrne students came from a large area across Tennessee, Mississippi and Arkansas.

Bishop Byrne was also the alma mater of Archbishop J. Peter Sartain.

[4] Influence1, a private charter school foundation, purchased the former Bishop Byrne property from the Catholic Diocese of Memphis and planned to open three charter schools at the location.

[5] Bishop Byrne competed in Division 2, Region A of the Tennessee Secondary School Athletic Association (TSSAA) along with: