Seminarians from eight dioceses across the Midwestern United States reside at the seminary and take classes at Marian University.

[1] The founder and former rector of the seminary from 2004 to 2016 was the Very Reverend Robert J. Robeson, PhD, a priest of the Archdiocese of Indianapolis.

Moriarty also assists with Spiritual Direction at St. Meinrad Seminary & School of Theology, as well as weekend ministry at Sts.

The first Vice Rector was Paul Etienne who was appointed bishop of the Diocese of Cheyenne, Wyoming on October 19, 2009.

[2] The Sixth and current (as of mid-2024) Vice Rector of the seminary is Father Peter Marshall, while continuing to serve as Pastor at St. Jude Parish, Indy.

Located northwest of downtown Indianapolis, Indiana, the seminary occupies 18.5 acres (7.5 ha).

Upon moving to the new location, the seminary had a capacity of 38 seminarians with plans to expand in order to house as many as 60 by the fall of 2014.

As of the start of the fall of 2013 the seminary has added on 10 new dorm rooms, and 2 priest apartments, this addition has expanded the occupancy to 60 men.

The chapel has hard wood ceilings and floors, which provide a suitable acoustic setting for the voices of the men praying or singing in common.

The reredos was custom designed for the seminary, to match the altar, which belonged to the late Bishop Chatard of Indianapolis.

The Bishop Simon Bruté College Seminary will work, in collaboration with Marian University, "to protect and develop the seeds of a priestly vocation, so that the students may more easily recognize it and be in a better position to respond to it" (Pastores dabo vobis, 63).