For three years, Bishop Timon – St. Jude High School was temporarily housed at Our Lady of Perpetual Help in Buffalo's old First Ward.

[2] Bishop Timon High School was founded by Roman Catholic priests of the Franciscan Order Minor, with the idea of providing a quality education at an affordable cost for the largely working-class Irish-American community within the proximity of its South Buffalo neighborhood location.

The Franciscan commitment to the needs of the area was the impetus for opening this all-boys college preparatory high-school to the local neighborhood's mostly blue-collar residents.

The primary building of the school is located at 601 McKinley Parkway which holds includes a newly completed of 2,800-square-foot athletic training facility.

In 1963 Timon opened a Freshman Annex located on Como Ave. named after Monsignor Nash of Holy Family Parish to accommodate its growing enrollment during its peak years of the 60s and 70s.