Bishop William Wallace Duncan House, also known as the DuPre House, is a historic home located at Spartanburg, Spartanburg County, South Carolina.

It is a two-story, asymmetrical, clapboard and cedar shingled dwelling in the Queen Anne style.

It has a high-pitched roof pierced by six chimneys, a decorative mosaic tile front porch landing, a massive wood shingle-clad cylindrical tower, and stained glass windows.

[4] It was listed on the National Register of Historic Places in 1976, delisted in 2005, and relisted in 2009.

This article about a property in Spartanburg County, South Carolina on the National Register of Historic Places is a stub.