Bishop Ramperto brought to Brescia the Benedictines, who constructed a church to which they transferred the relics of Saints Faustinus and Jovita; he also took part in the Council of Mantua of 827.

Bishop Notingus received the title of Count of Brescia for the see from Emperor Louis II in 844, so he and his successors became prince-bishops, civil rulers of the city and the countship.

Many struggles followed, in particular after Margrave Arduin of Ivrea, who had proclaimed himself King of Italy (1002), had slain the bishop of this city of holding allegiance to Holy Roman Emperor Henry II.

Berardo Maggi (1275), a Guelph (papal supporter in the Investiture Conflict), was made Duke and Count of the city, and constructed among other works two canals diverting the waters of the Rivers Chiese and Mella, in order to furnish the motive force for many factories.

Under Bishop Francesco de' Mareri (1418), the preaching of St. Bernardine of Siena wrought a great moral reform in the city of Brescia.

In conformity with the decrees of the Council of Trent, Domenico Bollani (1559) convened a diocesan synod (1574) and founded the seminary.

Cardinal Giovanni Alberto Badoer (1706) was a very zealous pastor, combating in an especial manner the Quietism which occurred his diocese.