The diocese extends across most of the historic county boundaries of Cheshire, including the Wirral Peninsula and has its see in the City of Chester where the seat is located at the Cathedral Church of Christ and the Blessed Virgin Mary, which was formerly the Benedictine Abbey of Saint Werburgh, being elevated to cathedral status in 1541.

The next bishop, however, transferred the see to Coventry on account of the rich monastery there, though he retained the episcopal palace at Chester.

The church was served by a small chapter of secular canons until 1093, when Hugh, Earl of Chester, converted it into a great Benedictine monastery, with the co-operation of St Anselm, then Prior of Bec, who sent Richard, one of his monks, to be the first abbot.

This monastery, though suffering loss of property both by the depredations of the Welsh and the inroads of the sea, prospered, and in the thirteenth, fourteenth, and fifteenth centuries the monks transformed their Norman church into a gothic building.

The first bishop was the Provincial of the Carmelites, John Bird, a doctor of divinity who had attracted the king's attention by his sermons preached against the pope's supremacy.

George Cotes, Master of Balliol and Fellow of Magdalen College, Oxford, and lecturer in theology, was appointed bishop by the Roman See.

The present diocese covers most of the traditional county of Cheshire, including the Wirral Peninsula and has its see in the City of Chester where the seat is located at the Cathedral Church of Christ and the Blessed Virgin Mary, which was formerly the Benedictine Abbey of Saint Werburgh, being elevated to cathedral status in 1541.