Many writers affirm that a certain St. Felix, martyred by the Vandals about 407, was Bishop of Nîmes, but Louis Duchesne questions this.

Other noteworthy bishops are: Urban II, coming to France to preach the crusade, consecrated the Cathedral of Nîmes in 1096 and presided over a council.

Clement IV (1265–1268), born at Saint Gilles, in this diocese, granted the monastery of that town numerous favors.

In consequence of disputes about the sale of grapes to the papal household, Innocent VI laid an interdict on Nîmes in 1358.

The following Saints are especially venerated in the present Diocese of Nîmes: St. Castor, Bishop of Apt (4th to 5th century), a native of Nîmes; the priest St. Theodoritus, martyr, patron saint of the town of Uzès; the Athenian St. Giles (AEgidius, seventh cent.