The Prince-Bishopric of Worms was an ecclesiastical principality of the Holy Roman Empire.

Located on both banks of the Rhine around Worms just north of the union of that river with the Neckar, it was largely surrounded by the Electorate of the Palatinate.

From the High Middle Ages on, the prince-bishops' secular jurisdiction no longer included the city of Worms, which was an Imperial Free City (the Free Imperial City of Worms) and which became officially Protestant during the Reformation.

The prince-bishops however retained jurisdiction over the Cathedral of Worms inside the city.

In 1795 Worms itself, as well as the entire territory of the prince-bishopric on the left bank of the Rhine, was occupied and annexed by France.