Bishopville Commercial Historic District is a national historic district located at Bishopville, Lee County, South Carolina.

It encompasses 48 contributing buildings in the central business district of Bishopville.

All of the buildings are used for commercial purposes such as stores, restaurants, offices and banks.

Two important buildings are the Seaboard Coastline Depot and the Palmetto Oil Mill.

This article about a property in Lee County, South Carolina on the National Register of Historic Places is a stub.