Bison is an unincorporated community and census-designated place (CDP) located on US Highway 81 in Garfield County, Oklahoma, United States, consisting of a 30-acre (12 ha) town plat.

[3] The community was named for nearby Buffalo Springs,[4] a historic stagecoach stop and a watering hole on the Chisholm Trail located about a mile north of Bison.

[5][6] Bison is home to a Catholic community, part of St. Joseph's parish under the Archdiocese of Oklahoma City.

[7] The church was erected in 1909, followed by a two-story brick school building operated by the Sisters of the Divine Providence from 1911 to 1934, when the Adorers of the Blood of Christ took over.

[5] Bison is located in southern Garfield County on the west side of US Highway 81, which leads north 14 miles (23 km) to Enid, the county seat, and south 6 miles (10 km) to Hennessey.