In 1617, Ikeda Nagayuki was transferred from Tottori Domain and assigned 60,000 koku; however, his son Nagatsune died without heir in 1641.

Mizunoya Katsukata's grandson, Katsuyoshi died before an heir could be appointed, and the shogunate used this as an excuse to reduce the clan to hatamoto status and the domain fell to attainder.

Ōishi Kuranosuke had a bad reputation in Matsuyama for his arrogance and inflexible attitude, and under his control a comprehensive survey was conducted by the shogunate.

The 7th daimyō, Itakura Katsukiyo was a noted figure in the Bakumatsu period shogunate, serving as head of the rōjū following the assassination of Ii Naosuke and playing an important role on the side of the pro-Tokugawa forces in the Boshin War.

For this reason, Bitchū-Matsuyama invaded and occupied by the pro-imperial forces of Okayama Domain early in the war.