Bixby State Preserve is a nature reserve located in southwestern Clayton County, Iowa, in the midwestern United States.

Bixby State Preserve is one of the few places in the world to contain algific talus slopes and consequently has an ecosystem encountered in only a few other sites, all in the Driftless Area.

They are mainly elsewhere in Iowa, but also in southeastern Minnesota, southwestern Wisconsin and northwestern Illinois.

In winter and early spring comparatively warm air rises from the elaborate system of sinkholes, causing cold moist air to be drawn into the north-facing talus slopes and sent through fissures into ice caves, where it turns to ice on the walls of the cave.

In summer and fall, the system is reversed, with cool moist air venting to the talus slopes, creating a unique ecosystem.