It is located in the east of the krai and borders with Zonalny, Tselinny, Soltonsky, Krasnogorsky, Sovetsky, and Smolensky Districts, as well as with the territory of the City of Biysk.

The Biya, Katun, Bekhtemir, Shubenka, and Nenya Rivers flow through the district.

Pines, birches, aspens, alders, sorbus, viburnum, bird cherries, and poplar grow in this area.

[citation needed] Within the framework of administrative divisions, Biysky District is one of the fifty-nine in the krai.

[8] The basic economy in the district is farming, including the production of grain, sugar beets, milk, meat, and livestock.