[6] The black-fronted titi is endemic to the Atlantic forest region of Brazil[7][8][4] and has a home range averaging 20 hectares (49 acres).

[12] Predators of the black-fronted titi include the harpy eagle, owls, hawks, falcons, tayra, jaguarundi, ocelot, margay, oncilla, pumas, jaguars, large snakes, and other, larger primates (such as howler monkeys).

[5][3] Black-fronted titis are particularly vulnerable to harpy eagle attacks when they move to the upper portion of the canopy to sunbathe on cold mornings.

[5] The black-fronted titi is socially monogamous[13][5][4] and is typically found in a group of two to six individuals, which includes the adult pair and their offspring.

[17] Characteristic of the Callicebinae subfamily, black-fronted titis can be observed with interwoven tails, a behavior thought to reinforce pair bonds and strengthen social relationships.

[18][19][20] The black-fronted titi is classified as near threatened by the IUCN due to extensive habitat loss, forest fragmentation, and an estimated population decline of more than 20% in the past 24 years.