This article lists the winners and nominees for the Black Reel Award for Outstanding Lead Performance in a Comedy Series.

The award recognizes an actor or actress who delivers an outstanding performance in a leading role of a comedy television series within the given eligible period.

The award was first presented at the 23rd Annual Black Reel Awards as a result of a merger between the Outstanding Actor and Outstanding Actress awards into a single gender-neutral award, with a total of ten nominees being selected.

Quinta Brunson is the inaugural winner for her performance in the second season of Abbott Elementary, for which she also won a Primetime Emmy Award.