[3] The song is about growing up in Pittsburgh, Pennsylvania, and also Khalifa's car, a yellow Dodge Challenger Hemi with black stripes.

In the year after it was released, "Black and Yellow" spawned dozens of remixes, parodies and remakes, both in the U.S. and internationally, many of them made in tribute to a local sports team.

[5][6][7] At Super Bowl XLV in 2011, which featured the Steelers competing against the Green Bay Packers, the Steelers used "Black and Yellow" as their fight song, while the Packers used a remix by Lil Wayne called "Green and Yellow", marking the first time both teams at the Super Bowl had used the same song.

It was filmed in Pittsburgh and features sights of the city, including the U.S. Steel Tower, BNY Mellon Center, PPG Place, William Penn Hotel, Citizens Bank Tower, Union Trust Building, One PNC Plaza, K&L Gates Center the Three Sisters and Smithfield Street bridges, Station Square, Shannon Hall of the Art Institute of Pittsburgh and the smoke stacks of the former U.S. Steel Homestead Works at The Waterfront adjacent to the city.

The official remix, "Black & Yellow (G-Mix)" features fellow American rappers Snoop Dogg and Juicy J, and singer T-Pain.

Some of the notable remakes include: In addition, a number of freestyle versions have been released, of artists rapping over "Black and Yellow"'s instrumental track, without any overt reference to the song or to sports teams.