The Blackberry Campaign is the name given to a May 1791 expedition led by Charles Scott against Native Americans of the lower Wabash Valley, primarily Wea, Kickapoo, Miami, and Potawatomi.

United States Secretary of War Henry Knox also wanted to capture "as many as possible, particularly women and children," whose freedom could then be a condition of future peace negotiations.

Native American forces, aware of a pending invasion, presumed the target of Scott's expedition was Kekionga, as the Harmar Campaign had been the previous year.

A battalion under James Wilkinson rushed to the river a fired into the crowded evacuation boats, which Scott reported "virtually destroyed all the occupants of five canoes.

Wilkinson described Kithtippecanunk as inhabited by French and Native Americans, living in about 70 "well finished" hourses, and that "by the books, letters, and other documents found there" to be in "close connection with, and dependent on, Detroit.

[11] Scott released 16 of the weakest captives, sending them with a message that the remaining prisoners could be recovered if the Native Americans would report to the U.S. fort on the Great Miami River to "bury the hatchet and smoke the pipe of peace.

[10] Joseph Brant, who had promoted a moderate position towards the United States at Niagara and Quebec before joining the rush to Kekionga, wrote that the Shawnee and Miami had vowed not to negotiate with a people "so wicked.

[13] That August, James Wilkinson, who had been offered a commission in the regular Army after his role in the Blackberry Campaign,[14] led a similar expedition starting from Fort Washington, resulting in the Battle of Kenapacomaqua.

Henry Knox considered the raids a success, writing "The consternation arising from the demonstration of their being within our reach must all tend to the great object, the establishment of peace.