The Blackstone Block Historic District encompasses what was once a waterfront business area in Boston, Massachusetts.

The district is bounded by Union, Hanover, Blackstone, and North Streets, not far from Quincy Market and Faneuil Hall.

1676 Blackstone Block Street Network was also designated by the Boston Landmarks Commission.

Town Cove is the area now occupied by Quincy Market to the north.

Furthermore, it was from this area that the rest of Boston was platted, with the "Boston Stone" marking the start of the original surveys still present, embedded in the wall of a 19th-century building on Marshall Street.