Effron's major coup came in 2005 when he advised Gillette on its $57 billion sale to Procter & Gamble, which was the largest mergers and acquisitions transaction of 2005.
Among Effron's other major deals are: In July 2006, Effron co-founded Centerview Partners along with Robert Pruzan, formerly CEO of North America at Dresdner Kleinwort Wasserstein and President of Wasserstein Perella & Co. Additional Centerview co-founders included Stephen Crawford, former co-president at Morgan Stanley, and Adam Chinn, a former partner at Wachtell Lipton.
In 2024, Centerview Partners ranked fourth among all banks for mergers and acquisitions revenue in the U.S.[9] Effron serves on the board of trustees of the Council on Foreign Relations (Vice-Chairman), Lincoln Center (Treasurer), the Metropolitan Museum of Art, New Visions for Public Schools, Partnership for New York City, and Princeton University.
[11] Effron contributes political and business commentary to outlets including the Financial Times, The Wall Street Journal, CNBC, Bloomberg and other publications.
[21][22] He stated on CNBC that Harris recognizes the importance of policy alignment with the private sector[22] and on Bloomberg TV that CEOs prefer stability and a free-market based economy.