His notable film work includes Leah Mckendrick's Scrambled, D. J. Caruso's Standing Up, Helen Hunt's Ride, Life of a King with Cuba Gooding Jr., and Love Is All You Need?, portraying the role of Bill Bradley.

[1] Soon after moving to Los Angeles, he performed the role of The Prince, opposite Broadway actress Ashley Brown, in the world symphonic premiere of Snow White and the Seven Dwarfs - A Symphonic Retelling, at the Walt Disney Concert Hall in Los Angeles, with the Hollywood Bowl Orchestra conducted by John Mauceri.

In 2014, Deadline Hollywood announced that Griffin had joined the cast of the twenty-something ensemble drama Flipside being executive produced by Mark Feuerstein in conjunction with Wind Dancer Films.

[7] Other major film roles include: Eric in Standing Up with Val Kilmer, J. Thomas Gaines in the chess drama Life of a King, and Bill Bradley in 'Love is All You Need?

[10] In 2024, Griffin played the hilarious, obsessive, cult leader "Owen" in Leah Mckendrick's Lionsgate feature film, Scrambled.

[13] In 2017, Griffin gave the keynote speech outside of the Georgia State Capitol building at a rally designed to push back against Congressional efforts to repeal the Affordable Care Act.

[17] Griffin travelled to the battleground state of North Carolina for the campaign the final week of the election, in a get out the vote blitz for the former Vice President and his running mate Kamala Harris, alongside other Hollywood performers including Common.