On 31 July French lawyer Eugène Poubelle signed her case, allowing her to work in Parisian hospitals on the condition that she did not use their intern title to enter the final exams to be a doctor.

Despite fierce competition, especially since she was a woman, her prize-winning dissertation helped her create her first consulting room in 1889, where she worked for the next 50 years.

In fact, she was the only woman of her time offered a medical teaching post by the Assistance Publique (Public Hospital System).

[2] An outspoken feminist, Edwards-Pilliet spent much of her time advocating for social reform, principally for women and children.

She was also a member of the Parti radical, which advocated for women's suffrage, and had dined on Christmas Day 1912 at the Paris Restaurant Mollard (designed by Édouard Niermans), with 'exiled' British suffragette leader Christabel Pankhurst, and fellow guests Jessie Murray Clark, Dorothy Hapgood and Irene Dallas and sister Hilda; according to The Suffragette newspaper, the evening ended with the singing of protest song "The March of the Women".