She was born in New Orleans, the daughter of Sam Thomas, a musician who played bass and trumpet in bands featuring Kid Howard and Jim Robinson.
Blanche began singing in her mid-teens at the Tick Tock Roof Garden on South Rampart Street, while also working as a waitress.
Blanche Thomas also sang regularly at Leon Prima's 500 Club, and at Sid Davila's Mardi Gras Lounge, and appeared fleetingly in Elvis Presley's 1958 film King Creole.
[2][3] In 1958, she recorded a version of "This Love of Mine" with a small group led by trumpeter Wallace Davenport, released on his Pontchartrain label.
She also toured Europe in 1975, as part of Dick Hyman's New York Repertory Company show, The Musical Life of Louis Armstrong.