It originates close to Cerro Altar and flows generally northward for 15 km (9.3 mi) until it joins the Juncal River, at an elevation of approximately 1,430 m (4,690 ft),[1] forming the Aconcagua River.

The mouth of the river is located close to Chile Route 60.

[1] The inferior course of the Río Blanco is adjacent to Río Blanco National Reserve.

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