Throughout his life, he worked on human rights issues as well as the identification of illegal and immoral aspects of United States government policy.

[1] Bonpane served as a Maryknoll priest in Guatemala and was assigned by the Cardinal of Central America as National Advisor to Centro Capacitacion Social, a center for university and high school students working in the field with indigenous people on matters of health, literacy and labor organization.

[1][8][9] In 1983, Bonpane garnered notoriety following an appearance on Hot Seat, a television program hosted by conservative commentator Wally George.

An argument about the U.S. invasion of Grenada turned into a dramatic physical confrontation when Bonpane overturned George's desk, live on-the-air, and stormed out of the studio.

(Guatemala: Occupied Country, Eduardo Galeano, Monthly Review Press, 1969) Blase Bonpane led investigative delegations to Nicaragua, Cuba, Mexico, Panama, Honduras, Costa Rica and Peru.