Blinn was founded in 1884 as Mission Institute by local minister Carl Urbantke with an original class of 3 ministerial students.

[5] In 1927, the Board of Trustees, under leadership of President Philip Deschner, organized a junior college.

On June 8, 1937, voters in Washington County levied a property tax for the creation of a public junior college district.

After some early struggles (including the campus nearly closing in 1946 due to fiscal issues), the college began to grow and do well under the leadership of Dr. Thomas Morris Spencer, one of the early public junior college pioneers in Texas.

The third Brazos County site, located in the former Bryan post office, continues to house the dental hygiene, radiologic technology, and workforce education programs.

[7] The groundbreaking ceremony for the Blinn College educational building took place on March 31, 2017.

[8] In 2022, Blinn opened a new $32 million administration building at RELLIS, incorporating 19 new classrooms in addition to offices for student enrollment.

[26] The home campus in Brenham has offered intercollegiate athletics since 1903 and has won 50 national championships since 1987.

The Division I football program is tied for the fourth most NJCAA national championships, with wins in 1995, 1996, 2006, and 2009.

Blinn's award-winning cheer and dance teams have won 18 combined NJCAA, NCA, and NDA National Championships since 2014.