[5] The game takes place in North Africa, the Pacific and Europe, and features the 6 different factions portrayed in the game that fought in their battle respective grounds during the war.

As its predecessor and the similar Sudden Strike games, Blitzkrieg 2 focuses on the battles of World War II rather than real-time strategy aspects like base building and resource extraction.

The second chapter is set in the North Africa Campaign, which ends with the capture of Tobruk by Axis forces.

The American campaign has its first 3 chapters in the Pacific theater, where the players lead your forces against the IJA (Imperial Japanese Army) and IJN (Imperial Japanese Navy) in a number of missions beginning shortly after the attack on Pearl Harbor.

The final chapter of the American campaign is set in the German Ruhr in 1945, during the invasion of Germany.