It was released on October 14, 2014 through Nuclear Blast,[1] and is the band's first album with vocalist Steve "Zetro" Souza since 2004's Tempo of the Damned.

The album also saw a reunion with original guitarist Kirk Hammett, who plays the guitar solo on "Salt the Wound".

[3] Exodus promoted the album with its first concert tour with Souza since he left the band in 2004, due to a feud with guitarist Gary Holt.

[6] Asked in June 2012 if Exodus had plans to record a tenth studio album, bassist Jack Gibson stated that the band was "way overdue to do it."

"[7] Vocalist Rob Dukes stated that the album was going to be "fast and short", and added, "everybody fucking complained about how long the last one was, we're, like, 'Fuck 'em!

I think Andy [Sneap, producer of Exhibit B: The Human Condition] is taking some time off; I don't know if he's gonna do it with us again.

"[8] In an October 2013 interview with The Washington Times, guitarist Gary Holt stated that he would take a break from touring with Slayer until April to focus on finishing the new Exodus album.

[10][11] Asked about the progress of the songwriting sessions for drummer Tom Hunting replied, "It's a pretty old-school process, actually.

"[12] Gibson indeed ended up being responsible for engineering the guitar and vocal tracks; he has been working with Pro Tools for other projects and eventually took a course on how to operate the software himself.

[13] By March 2014, Exodus had begun recording their tenth album at Goats 'R Us Ranch & Studios in San Francisco Bay Area in Northern California.

[19] Souza co-wrote at least one song on the album with bassist Jack Gibson and guitarist Lee Altus,[20] now known as "Body Harvest".

James Christopher Monger of AllMusic rated the album three-and-a-half stars out of five, and states, "Band and ex/current/deceased lead singer acrimony aside, the 11- track Blood In, Blood Out mostly crushes it, offering up a pulverizing set of textbook thrash-induced mayhem that somehow manages to sound both classic and vital.

[32] In April and May 2015, Exodus (along with Shattered Sun) was a supporting act for Testament on their Dark Roots of Thrash II tour.