The story of "Bloodties" details a civil war between the human and mutant populations of Genosha, incited by Magneto's former protégé Fabian Cortez.

As Luna's father Quicksilver has strong ties to the X-Men and her mother Crystal is a member of the Avengers, both teams become involved in the Genoshan conflict.

Cortez kidnaps Luna (the granddaughter of his former leader Magneto), and forces the child to witness the chaos that is engulfing Genosha's capital Hammer Bay.

Meanwhile, Nick Fury informs the Avengers of the situation in Genosha should not be in their worries until Valerie Cooper and the United Nations give the greenlight to them.

When Crystal retrieves what was thought to be Luna, the Black Knight smacks her away, revealing to be a Genoshan Mutate warning the Avengers the end of Genosha is near.

Cortez readies an army of mutants and Mutates to eliminate the humans in Hammer Bay, while Quicksilver expresses rage that Magneto's message will come to fruition.

Near Hammer Bay, the X-Men (Cyclops, Storm, Gambit, Rogue, Bishop, Revanche, Jean Grey, Archangel, Iceman, and Quicksilver) are confronted by Cortez and his loyalists.

The Avengers arrive at Hammer Bay and encounter Exodus, who warns the heroes Magneto's will live on in Genosha once the humans in the country are exterminated.

Above Hammer Bay, Exodus and Sersi have a violent battle, leading the rest of the heroes to worry about Genosha's impending demise.

Inside the Helicarrier, Nick Fury shows footage of Genosha's deteriorating state to the West Coast Avengers, with the Black Widow sadly admits that prayer is all they have right now.

After holding them back, Professor X launches a psychic attack on Exodus, allowing the Black Knight to knock him down and save Luna.

A second lasting effect was that it led to the official dissolution of the West Coast branch of the Avengers, until its revival by Hawkeyes Clint Barton and Kate Bishop, and the initial formation of the team Force Works.