The song was released as the lead single from the album on July 2, 2012, by RCA Records, shortly after a demo version leaked on to the internet.

[3][6] Prior to the song's release, Pink considered titling it "Blow Me", but RCA Records added the bracketed "One Last Kiss" to avoid a double entendre.

[9][10][11] Marc Hogan of Spin and Jonathan Bogart of The Atlantic both noted similarities between "Blow Me (One Last Kiss)" and Modest Mouse's 2004 song "Float On", referring to the "punchy" rock riffs used.

[16] Greg Kot of the Chicago Tribune characterized "Blow Me (One Last Kiss)" as "bittersweet" and described the song as a representation of "heart-break, exasperation and [Pink's] desire to move on" from a relationship.

[14] On a similar note, Andrew Hampp from Billboard wrote that the song "finds the singer contemplating the end of her tumultuous 10-year relationship" with her husband Carey Hart.

[17] Pink explained that the lyrics were partly inspired by the year-long separation from her husband, as well as feeling frustrated over different situations in love or life.

[2][18][19] The opening lines, "White knuckles / And sweaty palms from hangin' on too tight / Clenched shut jaw / I've got another headache again tonight", describe self-destructive behavior and people's fear of losing something important.

[23] "Blow Me (One Last Kiss)" was released for streaming via Pink's website on July 2, 2012,[5][23] and for digital download in various countries the following day, through RCA Records.

[8] In Germany, the song was released for digital download and serviced to contemporary hit radio stations on July 6, 2012, through Sony Music.

In her review of The Truth About Love, Sarah Grant from Consequence of Sound compared the song to Kelly Clarkson's 2009 single, "My Life Would Suck Without You", and noted that Pink "has a special knack for filtering the current trend through her own musical lens".

[7] Writing for MTV News, Jocelyn Vena highlighted the song's "anthemic chorus" and "lyrical edge", further commenting that it contains "the signature girl-power sass that Kelly frequently has on her own tracks".

[9] While reviewing the album, USA Today's writer Elysa Gardner praised the song's lyrics for portraying "a blunt, graphic assessment of a failed relationship".

[32] In his review of the song, Andrew Hampp of Billboard awarded a rating of 85 out of 100 and deemed it as a return to form, and an "empowering breakup anthem in the vein of 'So What'".

[12] Tanner Stransky of Entertainment Weekly viewed the song's lyrics as "sharp" and described its music direction as "something that Clarkson could have featured on her own album".

[35] Robert Copsey of Digital Spy selected the song as an example for "[putting] to bed any notion that [Pink] lost her sense of humour or the ability to laugh at herself".

[10] In a mixed review, Sal Cinquemani from Slant Magazine commended the song's "catchy" production, but criticized Pink for "playing it safe".

[54] "Blow Me (One Last Kiss)" peaked at number eight on the New Zealand Top 40 Singles chart and later received a platinum certification by Recorded Music NZ (RMNZ) for sales of 15,000 units in the country.

[55][56] The music video for "Blow Me (One Last Kiss)" was directed by Pink's longtime collaborator Dave Meyers and filmed at Malibu Creek State Park, California.

[66] Kyle Anderson of Entertainment Weekly said Pink "casts herself as a fancy lass" from the silent film era "who has had enough with the men in her life".

[59] James Montgomery of MTV News called the video "a whimsical nod to classic French cinema" and praised the "overwrought emoting and smoky, dream-like scenery".

[5] For the performance of the song, Pink wore a sleeveless white T-shirt, short black pants, suspenders, fishnets, and heels.

[68] The performance began with the intro of "Get the Party Started" (2001) as Pink stood on a small platform, playing on a keyboard and a drum pad.

[70][71] On September 10, 2012, as part of the promotion of The Truth About Love, Pink sang the song on The Ellen DeGeneres Show and Le Grand Journal.

[95] In 2012, Marley Rose (Melissa Benoist) and Wade "Unique" Adams (Alex Newell) performed "Blow Me (One Last Kiss)" in the 2012 Glee episode "The Role You Were Born to Play".