The 22,500 capacity venue is the home ground for the Penrith Panthers who play in the National Rugby League (NRL).

It was briefly featured in a 2009 60 Minutes episode titled "Brute Force" showing Public Order & Riot Squad officers across Sydney.

A new video screen was purchased from Subiaco Oval in Perth in 2018 and was installed prior to the start of the 2019 NRL season at the Family Hill end.

[7] On 9 December 2021, Premier, Dominic Perrottet and Stuart Ayres, minister for Tourism and Western Sydney, alongside Penrith Panthers players Nathan Cleary and Brian To'o officially announced the new stadium.

[9] However, in July 2022, the NSW government entered talks with the Penrith Paceway, a major horse racing facility, to buy the land it sits on to build a brand new stadium.

In February 2023, the ground hosted the 2023 World Club Challenge clash between two-time reigning NRL premiers the Penrith Panthers and four-time defending Super League champions St Helens R.F.C.

[16] Penrith Stadium was sponsored by Credit Union Australia, who previously held the naming rights, from early 2006 until 31 October 2010.

[20] In the National Rugby League competition, the Penrith Panthers club have played at this stadium, as their home ground, ever since making their first grade appearance in 1967.

On 16 September 2017 the venue hosted an international women's friendly football game when the Matildas defeated Brazil 2–1 in front of a crowd of 15,089.