The company was initially founded in 2008 under the project name Bio.Diaspora by Dr. Kamran Khan, a professor at the University of Toronto and infectious disease specialist at St. Michael's Hospital.

[3] The company is said to have “attracted interest from public health, biodefense and industry groups worldwide, all of which are looking for real-time, global epidemic intelligence to protect their interests.”[4] Bio.Diaspora produced a report in 2009 titled “An Analysis of Canada’s Vulnerability to Emerging Infectious Disease Threats via the Global Airline Transportation Network” with funding from the Public Health Agency of Canada.

It sent an alert to its customers on December 31, 2019, and used data on airline tickets to accurately predict the virus' apparent travel to Bangkok, Seoul, Taipei, and Tokyo.

[16] On March 23, 2020, Canadian Prime Minister Justin Trudeau announced that it had contracted BlueDot through the Public Health Agency of Canada for COVID-19 modelling and monitoring.

[17] In May 2022, it was revealed that BlueDot had used Canadian citizens' cell phone data accessed under direction from PHAC to view a detailed snapshot of people's behaviour, including visits to the grocery store, gatherings with family and friends, time spent at home and trips to other towns and provinces.