It is set in the Marvel Cinematic Universe (MCU), sharing continuity with the films and other television series of the franchise.

The season is produced by ABC Signature Studios, Marvel Television, and Wandering Rocks Productions, with Pokaski serving as showrunner.

"[25] Olivia Holt, Aubrey Joseph, Gloria Reuben, Andrea Roth, and Emma Lahana return to star in the season as Tandy Bowen / Dagger, Tyrone Johnson / Cloak, Adina Johnson, Melissa Bowen and Brigid O'Reilly, respectively.

[14] Season two added Brooklyn McLinn, Dilshad Vadsaria and Cecilia Leal to the cast as Andre Deschaine, Lia Dewan and Mikayla Bell respectively.

[28] A newspaper article about Luke Cage, written by Karen Page, including a picture of the titular character portrayed by Mike Colter, is prominently featured in the season.