Blythedale is a village in northeast Harrison County, Missouri, United States.

[6] Blythedale is located at the intersection of Missouri routes N and T approximately 2.5 miles east of Interstate 35.

The East Fork of Big Creek flows past the west side of the community.

[7] According to the United States Census Bureau, the village has a total area of 0.31 square miles (0.80 km2), all land.

The racial makeup of the village was 99.14% White, 0.43% Pacific Islander, and 0.43% from two or more races.

29.0% of all households were made up of individuals, and 22.0% had someone living alone who was 65 years of age or older.

About 26.8% of families and 32.4% of the population were below the poverty line, including 53.8% of those under the age of eighteen and 18.9% of those 65 or over.