It is a single-story island-type station in the Streamline Moderne architectural style, with rounded corners, and projecting canopies on either side.

The main entrance also has a rounded canopy over it, and a vertical sign rising above, advertising the Greyhound Bus Lines.

[2] The station was designed by architects William Nowland Van Powell and Ben Watson White.

Since 2010, it has served as an office, museum, and visitor center for Main Street Blytheville.

This article about a property in Mississippi County, Arkansas on the National Register of Historic Places is a stub.