It was directed by David Flores, from a script by Chase Parker and Sam Wells, and was filmed in Sofia, Bulgaria.

In the film, an FBI agent seeks help from a herpetologist and a marine biologist to release a specially bred Boa to hunt a gigantic Python that has been attacking humans.

Enjoying this spectacle is multi-millionaire casino owner Broddick (Adam Kendrick) and his girlfriend Eve (Angel Boris).

The caller, Ramon informs Broddick at York, Pennsylvania that his "package" has arrived overseas from South America and is being delivered.

One of the men is startled and fires his gun, accidentally hitting the main control circuit on the back of the truck.

The main door of the sealed container opens, and an abnormally large, nightmarish reticulated python, about 80 ft (24 m) long and 12 t (26,000 lb), emerges and kills the group.

Broddick reveals his plan to bring extreme big-game hunting to the city, as yet another pastime for the mega-wealthy, and the python is to be the quarry.

He enlists herpetologist Dr. Steven Emmett (David Hewlett) and marine biologist Monica Bonds (Jaime Bergman) to devise a plan to stop the python.

They plan to merge Monica's dolphin-camera headgear and tracking system to Dr. Emmett's giant 70 ft (21 m) long, 11.5 t (25,000 lb), genetically enhanced Scarlet Boa named Betty.

The trio, now joined by a backup team of FBI agents and US Army soldiers, transports Betty to the water treatment facility.

It was later released by Sony Pictures Home Entertainment as a part of a multi-film pack, which included Chupacabra Terror, Frankenfish, and Lake Placid 3.