Every football season in which he played, Blake was a member of the Southern Intercollegiate Athletic Association (SIAA) championship team and unanimously selected All-Southern.

[6] Blake was Vanderbilt University’s first athlete to earn 16 letters,[7] participating in football, basketball, baseball, and track.

Blake was a prominent end for Dan McGugin's Vanderbilt Commodores football teams in 1903 and from 1905 to 1907.

In 1915, John Heisman called Blake one of the greatest players in Vanderbilt history, along with Ray Morrison and Owsley Manier.

[6] Vanderbilt won a major intersectional contest in 1906 when it defeated Carlisle 4–0 via a single, 17-yard Blake drop kick,[9] "the crowning feat of the Southern Intercollegiate Athletic Association season.

[9] He made Walter Camp's All-America Honorable Mention in 1907, as well as the first team All-American selection of Michigan coach Fielding Yost.

Blake threw the pass to Stein Stone on a trick double-pass play which set up the score to beat Sewanee in 1907 for the SIAA championship, which was cited by Grantland Rice as the greatest thrill he ever witnessed in his years of watching sports.

[18] In 1910, Blake was awarded a law degree and returned to Vanderbilt for one season as an assistant football coach for Dan McGugin.