At Kentucky he won All-American honors his last two years (consensus in 1950) and co-captained a Wildcats team that captured the SEC championship.

In 1950, the three-year All-SEC selection was chosen the best SEC lineman by the Atlanta (GA) Touchdown and Birmingham (AL) Quarterback Clubs.

A stalwart defensive tackle on six Browns Eastern Conference and three (1954–1955, 1964) NFL championship teams, Gain started in five Pro Bowl games.

Gain interrupted his professional career in 1953 to serve in Korean War for the United States Air Force as a 1st Lieutenant.

[2] He was honored by the Pittsburgh (PA) Dapper Dan Club and was named to the West Virginia and Cleveland Sports Hall of Fame.