Wayne Robert Hoffman (December 13, 1917 – April 13, 2005) was a U.S. American football running back in the NFL for the Washington Redskins and Los Angeles Rams.

Hoffman was an All-American college football player at the University of Southern California and was selected in the ninth round of the 1940 NFL draft.

Hoffman and the Trojans won the Rose Ball in 1938 and 1939 against Duke and Tennessee respectively.

[2] One of Hoffman's greatest highlights was when he tackled a UCLA player at the goal line to preserve a trip to the rose bowl.

This biographical article relating to an American football running back born in the 1910s is a stub.