Sadowski batted left-handed, threw right-handed, stood 6 feet (1.83 meters) tall and weighed 175 pounds (79 kilograms) during his active career.

Bo Sadowski signed with his hometown St. Louis Cardinals (the team that first signed pitcher Sadowski as well) in 1955 and made his debut (and only) appearance for the Redbirds on September 16, 1960, when he grounded out and walked against Stu Miller of the San Francisco Giants during a 6–2 defeat at Busch Stadium.

Following the 1960 campaign, he was traded to the Philadelphia Phillies, who recalled him from the Buffalo Bisons of the Triple-A International League for a more extended 16-game trial during 1961.

Sadowski returned to the minor leagues in 1964, and played six more years, almost exclusively at the Triple-A level, for several organizations.

As a major leaguer, Sadowski batted .222 with 73 hits, including nine doubles, three triples, seven homers and 46 RBI.