[4] Bones began his radio career at age 17 at the campus station of Henderson State University, KSWH-FM "The Pulse".

[citation needed] While still in college, Bones went to work as a station hand at KLAZ in Hot Springs, Arkansas, but was put on the air within a few days of being hired.

He then worked for radio station (KLAL), which led to his hosting The Bobby Bones Show on KHFI-FM in Austin, Texas.

At the height of his popularity, Bones was offered a job outside of radio but ultimately chose to remain with Clear Channel (now iHeart Media).

His co-host is Amy, and features Producer Eddie, Lunchbox, Raymundo, Morgan Number 2, Mike D., Abby, and Scuba Steve.

[10] Luke Bryan, John Mayer, Taylor Swift, Garth Brooks, Ed Sheeran, Blake Shelton, Tim McGraw, Lady Antebellum, Jason Aldean, Dierks Bentley, and more have been featured in interviews on the morning show.

In February 2013, The Bobby Bones Show was nationally syndicated through iHeart Media-owned Premiere Networks[11] and was made available via iHeartRadio.com and the iHeartRadio mobile app.

[18] Bones is also the host of the podcast “The Bobbycast” where he interviews singers/songwriters of all genres[19] which The Washington Post dubbed as a "treasure trove of unusually candid anecdotes.

[21] In 2018, Bones was a guest mentor for season sixteen of American Idol (the first to air on ABC) during the top 24 round.

[citation needed] On December 31, 2021, Bones, along with Rachel Smith of Entertainment Tonight, hosted New Year's Eve Live: Nashville's Big Bash.

[citation needed] In 2022, Bones hosted the USA Network competition series Snake in the Grass.

[26] In September 2018, Bones was announced as one of the celebrities to compete on the 27th season of Dancing with the Stars, being paired with the professional dancer Sharna Burgess.

Trump had registered the phrase for "political action committee services" but not for its use on hats, t-shirts, duffel bags, and other apparel and accessories that Bones now had the rights to.

Two days later, on August 7, Bones tweeted, "hey @realDonaldTrump, if you donate 100k to @stjude, I will give you your clothing trademark back.

[34] Bones became the youngest ever inductee into the National Radio Hall of Fame during a ceremony on November 2, 2017, at the Museum of Broadcast Communications in Chicago.