Common topics and themes include technology, futurism, science fiction, gadgets, intellectual property, Disney, and left-wing politics.

The editors are Mark Frauenfelder, David Pescovitz, Carla Sinclair, and Rob Beschizza,[1] and the publisher is Jason Weisberger.

Associate editors included Gareth Branwyn, Jon Lebkowsky, Paco Nathan, and David Pescovitz.

[5] Over time, Frauenfelder was joined by four co-editors: Doctorow, Pescovitz, Jardin and Beschizza, all of whom previously contributed to Wired magazine.

Bloggers commenting on the change at the time speculated that it stemmed from "identity impersonators and idiot flamers" pretending to be co-editors.

[11] In 2004, the project incorporated as Happy Mutants LLC, and John Battelle became the blog's business manager.

Guests have included Charles Platt, John Shirley, Mark Dery, Tiffany Lee Brown, Karen Marcelo of Survival Research Laboratories, Johannes Grenzfurthner of monochrom, Rudy Rucker, Gareth Branwyn, Wiley Wiggins, Jason Scott of textfiles.com, Jessamyn West of librarian.net, journalists Danny O'Brien and Quinn Norton and comedian John Hodgman.

The rebuttal was widely reported, including on frequently viewed websites such as The Huffington Post[18] and ABC News.

[20] In November 2017,[21] the site was sued by Playboy, which alleged that a hyperlink to copyright-infringing content at Imgur and YouTube was itself illegal.

in August 2003 as a reply to a picture of a rash posted by editor Mark Frauenfelder in an attempt to get readers to diagnose it for him.

[27] It has also been used as an antidote for posts containing photos of a brain tumor, a man who pumped up the skin of his face with saline solution, many different ways to clean one's earwax, and a lengthy discussion of the Internet video "2 Girls 1 Cup".

[31] Offworld, a blog covering video games edited by Brandon Boyer, was added in November 2008.

[citation needed] Plans to revive the Offworld site were announced in 2015, with Leigh Alexander as Editor-in-Chief and Laura Hudson as Editor.

[33] Leigh Alexander and Laura Hudson left Offworld in early 2016 after publishing a collection of selected articles, successfully crowdfunded on Kickstarter in March 2016.

[46] In commentary attached to that blog entry, "many commenters surmised that they had something to do with Blue's suing to stop a porn star from also using the name Violet Blue", and many commenters found the removal troubling, but Xeni Jardin said that she hoped she would not have to make the reasons public.