Ultimately, the variation of foot morphology within this genus is primarily due to natural selection.

[8] Bolitoglossa rostrata and B. subpalmata are two rare examples of poisonous salamanders within their genus.

It is particularly toxic to certain snake species, rendering them immobile and unresponsive to external stimuli upon initial contact.

The main differences that have developed from natural selection affect the skull and bones of the feet in these salamanders.

[11] The first documented case of hybridization in tropical salamanders occurred between B. frankini and B. resplendens.

This hybridization has taken a pervasive effect on the morphology of B. resplendens, whereas B. frankini seemed to maintain its same physical structure.